IRAK4-IN-1

IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with IC50 of 7 nM.

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库存: 现货

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促销价

数量
1mg

￥687.00

550.00

- +
5mg

￥2062.00

1650.00

- +
10mg

￥3162.00

2530.00

- +
25mg

￥6362.00

5090.00

- +
50mg

￥9387.00

7510.00

- +
100mg

￥14425.00

11540.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajce47618
CAS: 1820787-94-7
别名:
分子式: C19H23N5O
分子量: 337.42
纯度: >98%
溶解度: DMSO : 14.29 mg/mL (42.35 mM);Water : < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with IC50 of 7 nM.

[1] Graham F Smith, et al. Bioorg Med Chem Lett . 2017 Jun 15;27(12):2721-2726.

Protocol

Animal experiment:

Rats[1] In the TLR driven in vivo model, female Lewis rats are dosed with either vehicle or IRAK4-IN-1 (Compound 23; 3, 10, 30, and 100 mg/kg; p.o.) dosed at 1 h prior to stimulation with Resiquimod, R848 (5 mg/kg, IP). At 1.5 h post R848 stimulation, blood samples are obtained from the animals and cytokine levels are measured.

参考文献:

[1]. Smith GF, et al. Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2721-2726.

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信号通路

生命科学

有机化学

无机化学

材料科学

IRAK4-IN-1

IRAK4-IN-1详情

Background

Protocol

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