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IRAK4-IN-1

IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with IC50 of 7 nM.

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  • 1mg
    ¥687.00
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  • 10mg
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    ¥6362.00
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  • 货号: ajce47618
  • CAS: 1820787-94-7
  • 别名:
  • 分子式: C19H23N5O
  • 分子量: 337.42
  • 纯度: >98%
  • 溶解度: DMSO : 14.29 mg/mL (42.35 mM);Water : < 0.1 mg/mL (insoluble)
  • 储存: Store at -20°C
  • 库存: 现货

Background

IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with IC50 of 7 nM.


[1] Graham F Smith, et al. Bioorg Med Chem Lett . 2017 Jun 15;27(12):2721-2726.

Protocol

Animal experiment:

Rats[1] In the TLR driven in vivo model, female Lewis rats are dosed with either vehicle or IRAK4-IN-1 (Compound 23; 3, 10, 30, and 100 mg/kg; p.o.) dosed at 1 h prior to stimulation with Resiquimod, R848 (5 mg/kg, IP). At 1.5 h post R848 stimulation, blood samples are obtained from the animals and cytokine levels are measured.

参考文献:

[1]. Smith GF, et al. Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2721-2726.

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