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Adelmidrol

Adelmidrol is an analogue of palmitoylethanolamide (PEA) with anti-inflammatory activities.

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  • 货号: ajce47628
  • CAS: 1675-66-7
  • 别名: 阿地米屈
  • 分子式: C13H26N2O4
  • 分子量: 274.36
  • 纯度: >98%
  • 溶解度: DMSO : ≥ 34 mg/mL (123.92 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

Adelmidrol is an analogue of palmitoylethanolamide (PEA) with anti-inflammatory activities.

Protocol

Animal experiment:

Mice[1]Male adult CD1 mice (25-30 g) and male mice (20-27 g) are placed in a controlled environment and maintained on a 12-hour light/dark cycle with food and water available ad libitum. Mice are casually divided into the following groups (10 in each group) (1)Sham+vehicle group: Vehicle solution (saline) is given by oral administration for 4 days. (2) Sham+Adelmidrol (10 mg/kg): Administered o.s. for 4 days. (3) DNBS+vehicle: Mice are injected by DNBS as described, and vehicle (saline) is given o.s. each day for 4 days, starting 60 minutes after the injection of DNBS. (4) DNBS+Adelmidrol (10 mg/kg): Mice are injected by DNBS as described, and Adelmidrol (10 mg/kg) is given o.s. each day, starting 60 minutes after administration of DNBS[1].

参考文献:

[1]. Cordaro M, et al. Adelmidrol, a Palmitoylethanolamide Analogue, as a New Pharmacological Treatment for the Management of Inflammatory Bowel Disease. Mol Pharmacol. 2016 Nov;90(5):549-561.

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