Ginkgetin

A biflavonoid with diverse biological activities

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5mg

￥1625.00

1300.00

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10mg

￥2612.00

2090.00

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Background

Ginkgetin is a biflavonoid that has been isolated from G. biloba and has diverse biological activities, including pro-apoptotic, antiproliferative, anti-inflammatory, anti-atherosclerosis, and neuroprotective properties.^1,2,3,4 It inhibits the proliferation of OVCAR-3 ovarian and HeLa cervical cancer cells (EC₅₀s = 3 and 5.2 μg/ml, respectively) and induces apoptosis and caspase-3 cleavage in OVCAR-3 cells when used at a concentration of 3 μg/ml.¹ Topical ginkgetin (20 μg/ear) reduces ear edema and prostaglandin E₂ levels in a mouse model of chronic skin inflammation induced by phorbol 12-myristate 13-acetate .² It decreases the thickness of the intima-media and lipid plaque deposition in the thoracic aorta in a rat model of high-fat diet-induced atherosclerosis when administered at a dose of 100 mg/kg.³ Ginkgetin (0.8 mg/kg per day) improves sensorimotor coordination and increases the time spent on a rotating bar in a mouse model of Parkinson's disease induced by MPTP.⁴

1.Su, Y., Sun, C.M., Chuang, H.H., et al.Studies on the cytotoxic mechanisms of ginkgetin in a human ovarian adenocarcinoma cell lineNaunyn Schmiedebergs Arch. Pharmacol.362(10)82-90(2000) 2.Lim, H., Son, K.H., Chang, H.W., et al.Effects of anti-inflammatory biflavonoid, ginkgetin, on chronic skin inflammationBiol. Pharm. Bull.29(5)1046-1049(2006) 3.Lian, N., Tong, J., Li, W., et al.Ginkgetin ameliorates experimental atherosclerosis in ratsBiomed. Pharmacother.102510-516(2018) 4.Wang, Y.Q., Wang, M.Y., Fu, X.R., et al.Neuroprotective effects of ginkgetin against neuroinjury in Parkinson's disease model induced by MPTP via chelating ironFree Radic. Res.49(9)1069-1080(2015)