Methyl vanillate

Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.

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货号: ajce47830
CAS: 3943-74-6
别名: 香草酸甲酯
分子式: C9H10O4
分子量: 182.17
纯度: >98%
溶解度: DMSO : ≥ 100 mg/mL (548.94 mM);Water : 1.67 mg/mL (9.17 mM)
储存: Store at -20°C
库存: 现货

Background

Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.

Methyl vanillate (MV) activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro. It increases the expression of differentiation markers RUNX2, BMP2, ALP, and OCN in a dose-dependent manner. MV decreases and increases the expression of RANKL and OPG, respectively. Methyl vanillate dose-dependently elevates ALP activity in calvarial osteoblasts[1].

Methyl vanillate rescues trabecular or cortical femoral bone loss in the ovariectomized mice without inducing any significant weight changes or abnormality in liver tissue when administrated orally[1].

[1] Cha PH, et al. PLoS One. 2014, 9(1):e85546.