MDL 19301

MDL19301是一种非甾体抗炎剂。

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库存: 现货

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1mg

￥6687.00

5350.00

- +
5mg

￥10712.00

8570.00

- +
10mg

￥15912.00

12730.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

MDL 19301 is a nonsteroidal, anti-inflammatory agent.

Oral administration of MDL 19301 inhibits rat paw edema induced by carrageenan (ED30=4.8 mg/kg) or an Arthus reaction (ED30=8.2 mg/kg p.o.). The oral dose which induces gastric ulceration in 50% of fasted rats is greater than 1,000 mg/kg, demonstrating a more favorable therapeutic ratio than conventional nonsteroidal anti‐inflammatory agents. The anti-inflammatory activity of MDL 19301, but not that of MDL 16,861, is attenuated by co-administration of an inhibitor of drug metabolite (SKF525A). This suggests that MDL 19301 is a prodrug of MDL 16,861 and this phenomenon would explain its lack of ulcerogenicity. Additional anti-inflammatory properties of MDL 19301 include inhibition of carrageenan pleurisy, adjuvant arthritis, and HOAc-induced writhing. Other pharmacological data indicate that MDL 19301 administration results in inhibition of prostaglandin synthesis; inhibition of arachidonic acid-induced, but not prostaglandin-E2-induced, diarrhea in mice; and inhibition of ex vivo arachidonic-acid-induced, but not ADP-induced, rat platelet aggregation. MDL 19301 and MDL 16,861 are unexpectedly weak antipyretic agents in rats[1].

[1]. NS Doherty, et al. Pharmacological properties of MDL 19,301: A novel, nonsteroidal, anti‐inflammatory agent. Drug Dev Res 1989 16(1) 31-44