ACTH 11-24 (Adrenocorticotropic Hormone (11-24))

ACTH 11-24 (Adrenocorticotropic Hormone (11-24)) 是一种促肾上腺皮质激素 (ACTH) 受体拮抗剂。

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1mg

￥825.00

660.00

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5mg

￥1650.00

1320.00

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10mg

￥2250.00

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货号: ajce48150
CAS: 4237-93-8
别名: 促肾上腺皮质激素-(11-24)-十四肽,Adrenocorticotropic Hormone (11-24)
分子式: C77H134N24O16
分子量: 1652.04
纯度: >98%
溶解度: Soluble in Water
储存: Store at -20°C, protect from light, stored under nitrogen
库存: 现货

Background

ACTH (11-24) is a fragment of adrenocorticotrophin, acts as an antagonist of adrenocorticotropic hormone (ACTH) receptor, and induces cortisol release.

ACTH (11-24) acts as an antagonist of adrenocorticotropic hormone receptor[1]. ACTH (11-24) induces cortisol secretion submaximally in freshly dispersed or cultured beef adrenal cortical cells. The maximal cortisol release by ACTH (11-24) is enhanced by forskolin but inhibited by calcium channel blockers[2].

ACTH (11-24) blocks electroacupuncture (EA) anti-edema but not EA anti-hyperalgesia in rats[1].

[1]. Li ZG, et al. Adrenocorticotropin(1-10) and -(11-24) promote adrenal steroidogenesis by different mechanisms. Endocrinology. 1989 Aug;125(2):592-6. [2]. Li A, et al. Electroacupuncture activates corticotrophin-releasing hormone-containing neurons in the paraventricular nucleus of the hypothalammus to alleviate edema in a rat model of inflammation. BMC Complement Altern Med. 2008 May 12;8:20.