Clioquinol (Iodochlorhydroxyquin)

A metal-chelating antimicrobial agent

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库存: 现货

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1g

￥537.00

430.00

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5g

￥975.00

780.00

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货号: ajce48398
CAS: 130-26-7
别名: 氯碘羟喹,Iodochlorhydroxyquin
分子式: C9H5ClINO
分子量: 305.5
纯度: >98%
溶解度: DMSO : ≥ 53.33 mg/mL (174.57 mM);Water : < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

Clioquinol is a metal-chelating antimicrobial agent with neuroprotective properties.^1,2,3 It inhibits the growth of A. fumigatus with MIC values of 1, >32, 8, and 16 ?g/ml in media containing no metal, iron, zinc, and copper, respectively.¹ Clioquinol (37 mg/kg) decreases neuronal loss in the substantia nigra pars compacta (SNc) and increases time spent in the novel arm of a Y-maze in the α-synuclein hA53T transgenic mouse model of Parkinson's disease.² It reduces brain atrophy and iron content, increases nigral tyrosine hydroxylase phosphorylation, and rescues behavioral impairments in the rotarod and Y-maze tests in tau knockout mice.³

1.Ben Yaakov, D., Shadkchan, Y., Albert, N., et al.The quinoline bromoquinol exhibits broad-spectrum antifungal activity and induces oxidative stress and apoptosis in Aspergillus fumigatusJ. Antimicrob. Chemother.72(8)2263-2272(2017) 2.Finkelstein, D.I., Hare, D.J., Billings, J.L., et al.Clioquinol improves cognitive, motor function, and microanatomy of the α-Synuclein hA53T transgenic miceACS Chem. Neurosci.7(1)119-129(2016) 3.Lei, P., Ayton, S., Appukuttan, A.T., et al.Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouseNeurobiol. Dis.81168-175(2015)