Tylosin (Tylosin A)

A macrolide antibiotic

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50mg

￥537.00

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货号: ajce48410
CAS: 1401-69-0
别名: 泰乐菌素; Tylosin A
分子式: C46H77NO17
分子量: 916.1
纯度: >98%
溶解度: DMSO : ≥ 100 mg/mL (109.16 mM);Water : < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

Tylosin is a macrolide antibiotic produced by S. fradiae that has bacteriostatic activity against Gram-positive bacteria.¹ It is a mixture of tylosin A, B, C, and D, with tylosin A contributing 80% of its bacteriostatic activity. Tylosin has MIC values of 9.6, 16.4, 0.1, 1, and 0.5 μg/ml for F. necrophorum, A. pyogenes, M. gallisepticum, S. aureus, and S. uberis, respectively.²,³,⁴ Formulations containing tylosin have been used for the prevention of liver abscesses in cattle.³ Tylosin is an environmental contaminant because it is not fully metabolized by treated livestock and enters the environment through manure-based fertilizers.⁵

1.Arsic, B., Barber, J., ?iko?, A., et al.16-membered macrolide antibiotics: A review.Int. J. Antimicrob. Agents30238-30280(2017) 2.Bonnier, M., Doré, C., Amédéo, J., et al.In vitro activity of tylosin and tilmicosin against cocci isolated from bovine mastitisRevue Méd. Vét.157(10)486-489(2006) 3.Nagaraja, T.G., and Chengappa, M.M.Liver abscesses in feedlot cattle: A reviewJ. Anim. Sci.76(1)287-298(1998) 4.Jordan, F.T., and Knight, D.The minimum inhibitory concentration of kitasamycin, tylosin and tiamulin for Mycoplasma gallisepticum and their protective effect on infected chicksAvian Pathol.13(2)151-162(1984) 5.Washington, M.T., Moorman, T.B., Soupir, M.L., et al.Monitoring tylosin and sulfamethazine in a tile-drained agricultural watershed using polar organic chemical integrative sampler (POCIS)Sci. Total. Environ.612358-367(2017)