Fexinidazole (HOE 239)

An antiparasitic agent

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库存: 现货

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5mg

￥375.00

300.00

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10mg

￥375.00

300.00

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50mg

￥537.00

430.00

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100mg

￥737.00

590.00

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货号: ajce48430
CAS: 59729-37-2
别名: 非昔硝唑; HOE 239
分子式: C12H13N3O3S
分子量: 279.31
纯度: >98%
溶解度: DMSO : 50 mg/mL (179.01 mM);Water : < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

Fexinidazole is an antiparasitic agent.¹ It is active against 15 strains of T. brucei, including T. b. rhodesiense, T. b. brucei, and T. b. gambiense (IC₅₀s = 0.95-3.31 ?M). Fexinidazole inhibits the growth of L. donovani at the promastigote and axenic amastigote stages (EC₅₀s = 5.6 and 2.8 ?M, respectively).² Fexinidazole (50 to 30 mg/kg per day) reduces parasitic burden and increases survival in a mouse model of infection with benznidazole-susceptible, -partially resistant, or -resistant T. cruzi.³ Formulations containing fexinidazole have been used in the treatment of African sleeping sickness and Chagas disease.

1.Su, L., Pan, P., Yan, P., et al.Role of vimentin in modulating immune cell apoptosis and infammatory responses in sepsisSci. Rep.9(1)5747(2019) 2.Wyllie, S.G., Patterson, S., Stojanovski, L., et al.The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasisSci. Transl. Med.4(119)119re111(2012) 3.Bahia, M.T., de Andrade, I.M., Martins, T.A.F., et al.Fexinidazole: A potential new drug candidate for Chagas diseasePLoS Negl. Trop. Dis.6(11)e1870(2012)