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  • Leu-AMS
    Leu-AMS的可视化放大

    Leu-AMS

    Leu-AMS是亮氨酰-tRNA合成酶(LRS)的有效抑制剂,其IC50值为22.34nM且能够抑制细菌的生长。

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    Leu-AMS的二维码
    • 库存: 现货
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    • 1mg
      ¥2037.00
      1630.00
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    • 5mg
      ¥6300.00
      5040.00
      - +
    • 10mg
      ¥9525.00
      7620.00
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    金额: ¥0.00
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    • 货号: ajce48484
    • CAS: 288591-93-5
    • 别名:
    • 分子式: C16H25N7O7S
    • 分子量: 459.48
    • 纯度: >98%
    • 溶解度: DMSO : ≥ 49.17 mg/mL (107.01 mM)
    • 储存: Store at -20°C
    • 库存: 现货

    Background

    Leu-AMS is a potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM and inhibits the growth of bacteria.


    Leu-AMS is proved to be a potent inhibitor of Leucyl-tRNA Synthetase (LRS) with an IC50 value of 22.34 nM. Leu-AMS is highly cytotoxic in both cancer cells and normal cells. Leu-AMS does not affect S6 kinase (S6K) phosphorylation at all. Leu-AMS inhibits the catalytic activity of LRS but does not affect the leucine-induced mTORC1 activation[1].


    [1]. Yoon S, et al. Discovery of Leucyladenylate Sulfamates as Novel Leucyl-tRNA Synthetase (LRS)-TargetedMammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitors. J Med Chem. 2016 Nov 23;59(22):10322-10328.

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