Puromycin (CL13900)

Puromycin 2HCl (CL13900) is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.

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Background

Puromycin 2HCl (CL13900) is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.

The antibiotic puromycin is produced by the actinoniycete, Streptornyces alboniger, and has been used as a tool for studying protein synthesis in a number of systems. [1] Puromycin can be used for the selection of recombinant cells from noncultured cells. [2]

Puromycin (aminonucleoside) inhibits protein synthesis leading to proteinuria & glomerulosclerosis/nephrosis.[4]

2HCl盐酸盐嘌呤霉素（Puromycin 2HCl，CL13900）是一种氨基核苷类抗生素，可作为蛋白质合成抑制剂。

嘌呤霉素抗生素由放线菌白色素链霉菌（Streptornyces alboniger）产生，并已用于许多系统中研究蛋白质合成。[1] 嘌呤霉素可用于从非培养细胞中选择重组细胞。[2]

嘌呤霉素（氨基核苷类）抑制蛋白质合成，导致蛋白尿和肾小球硬化/肾病综合征。[4]

[1] Darken MA. Pharmacol Rev. 1964, 16, 223-243. [2] Watanabe S, et al. Biol Reprod. 2005, 72(2), 309-315. [3] Chan C, et al. Pharmacol Res Perspect. 2017 Oct;5(5):e00359.