CIL56

An inducer of non-apoptotic cell death

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库存: 现货

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5mg

￥987.00

790.00

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10mg

￥1575.00

1260.00

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25mg

￥2937.00

2350.00

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50mg

￥4637.00

3710.00

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100mg

￥7450.00

5960.00

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货号: ajce48716
CAS: 300802-28-2
别名: 2,7-双(哌啶-1-基磺酰基)-9H-芴-9-酮肟,CA3
分子式: C23H27N3O5S2
分子量: 489.61
纯度: >98%
溶解度: DMSO : 50 mg/mL (102.12 mM);Water : < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

CIL56 is a small molecule that induces non-apoptotic cell death in a manner dependent on acetyl-CoA carboxylase 1 (ACC1), the rate-limiting enzyme in fatty acid synthesis.¹ HT-1080 cells lacking ACC1 exhibit 5-fold resistance to CIL56 treatment, indicating ACC1 activity sensitizes cells to CIL56-induced cell death. CIL56 (6.5 μM) induces accumulation of long-chain saturated, monounsaturated, and polyunsaturated fatty acids in HT-1080 cells in vitro.

1.Dixon, S.J., Winter, G.E., Musavi, L.S., et al.Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell deathACS Chem. Biol.10(7)1604-1609(2015)