Butylparaben (Butyl parahydroxybenzoate)

A paraben

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库存: 现货

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5g

￥537.00

430.00

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货号: ajce48752
CAS: 94-26-8
别名: 对羟基苯甲酸丁酯; Butyl parahydroxybenzoate; Butyl paraben; Butyl 4-hydroxybenzoate
分子式: C11H14O3
分子量: 194.23
纯度: >98%
溶解度: Insoluble in Water; ≥116.2 mg/mL in DMSO; ≥47.2 mg/mL in EtOH
储存: Store at -20°C
库存: 现货

Background

Butyl 4-hydroxybenzoate is a paraben that has been found in Microbulbifer.¹ It is active against the Gram-positive bacteria B. subtilis and S. aureus, yeast C. molischiana and S. cerevisiae, and fungi A. niger and P. chrysogenum (MICs = 75, 75, 60, 52, 55, and 45 mg/L, respectively). Butyl 4-hydroxybenzoate (300-1,000 ?M) decreases the viability of, and ATP and glutathione (GSH) levels in, HepG2 and human dermal fibroblast neonatal (HDFn) cells.² It binds to estrogen receptors in a concentration-dependent manner and increases uterine weight in immature and ovariectomized rats.³ Butyl 4-hydroxybenzoate has been found in influent and effluent wastewater.⁴ Formulations containing butyl 4-hydroxybenzoate have been used as preservatives in cosmetics, food, and pharmaceuticals.

1.Peng, X., Adachi, K., Chen, C., et al.Discovery of a marine bacterium producing 4-hydroxybenzoate and its alkyl esters, parabensAppl. Environ. Microbiol.72(8)5556-5561(2006) 2.Kizhedath, A., Wilkinson, S., and Glassey, J.Assessment of hepatotoxicity and dermal toxicity of butyl paraben and methyl paraben using HepG2 and HDFn in vitro modelsToxicol. In Vitro55108-115(2019) 3.Routledge, E.J., Parker, J., Odum, J., et al.Some alkyl hydroxy benzoate preservatives (parabens) are estrogenicToxicol. Appl. Pharmacol.153(1)12-19(1998) 4.Wang, W., and Kannan, K.Fate of parabens and their metabolites in two wastewater treatment plants in New York state, United StatesEnviron. Sci. Technol.50(3)1174-1181(2016)