Crotamiton

An ectoparasiticide and antipruritic

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数量
100mg

￥537.00

430.00

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Background

Crotamiton is an ectoparasiticide and antipruritic agent.^1,2,3 It blocks the mouse transient receptor potential vanilloid 4 (TRPV4) channel expressed in HEK293 cells in a calcium-dependent manner (IC₅₀s = 223.5 and 15.5 μM in buffer containing 0 and 2 mM calcium, respectively).² It inhibits scratching behavior in mice induced by the TRPV4 agonist GSK1016790A . Topical application of crotamiton (0.025 g of a 10% ointment) also inhibits scratching behavior in mice induced by histamine, serotonin , and the proteinase-activated receptor 2 (PAR2) agonist SLIGRL-NH₂ .³ Formulations containing crotamiton have been used to eradicate scabies and in the treatment of symptomatic pruritic skin.

1.Goldust, M., Rezaee, E., and Raghiafar, R.Topical ivermectin versus crotamiton cream 10% for the treatment of scabiesInt. J. Dermatol.53(7)904-908(2014) 2.Kittaka, H., Yamanoi, Y., and Tominaga, M.Transient receptor potential vanilloid 4 (TRPV4) channel as a target of crotamiton and its bimodal effectsPflugers Arch.469(10)1313-1323(2017) 3.Sekine, R., Satoh, T., Takaoka, A., et al.Anti pruritic effects of topical crotamiton, capsaicin, and a corticosteroid on pruritogen-induced scratching behaviorExp. Dermatol.21(3)201-204(2012)