AQ-13 dihydrochloride

AQ-13dihydrochloride是一种能有效对抗恶性疟原虫(Plasmodiumfalciparum)的抗氯喹啉抗疟药。

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库存: 现货

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价格

促销价

数量
5mg

￥987.00

790.00

- +
10mg

￥1625.00

1300.00

- +
25mg

￥3262.00

2610.00

- +
50mg

￥4850.00

3880.00

- +
100mg

￥8100.00

6480.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

AQ-13 dihydrochloride is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum.

Slight decreases in the PCE/RBC ratio are observed in male and female rats treated with CQ and in females only treated with AQ-13; however, none of these changes is statistically significant[1].

[1]. Riccio ES, et al. Genetic toxicology testing of the antimalarial drugs chloroquine and a new analog, AQ-13. Environ Mol Mutagen. 2001;38(1):69-79.

Protocol

Animal experiment:

Rats[1]Male and female Sprague-Dawley rats are used and are 8-9 weeks of age at the time of dose administration. Micronucleus evaluations are conducted in conjunction with repeatdose toxicity studies. Rats are orally administered AQ-13 or CQ in water. Rats are given a “loading dose” followed by maintenance doses of one-half the loading dose administered 12 hr later and daily thereafter for 6 additional days[1].

参考文献:

[1]. Riccio ES, et al. Genetic toxicology testing of the antimalarial drugs chloroquine and a new analog, AQ-13. Environ Mol Mutagen. 2001;38(1):69-79.