PGLa是一种抗菌肽,对革兰氏阳性菌和阴性菌均具有抑菌作用。
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PGLa is an antimicrobial peptide. PGLa is known to be bacteriostatic against both Gram-positive and Gram-negative bacteria.
PGLa is known to be bacteriostatic against both Gram-positive and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Streptococcus pyogenes, and Staphylococcus aureus), without much selectivity between the two types of bacterial cells. PGLa is synthesized as a native (the wild type) peptide and as a mutant with a norleucine instead of methionine at position 2Met (designated PGLa(Nle)).
[1]. Radchenko DS, et al. Does a methionine-to-norleucine substitution in PGLa influence peptide-membrane interactions? Biochim Biophys Acta. 2016 Sep;1858(9):2019-27.
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