Kojic acid

A tyrosinase inhibitor

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100mg

￥537.00

430.00

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货号: ajce48972
CAS: 501-30-4
别名: 曲酸
分子式: C6H6O4
分子量: 142.11
纯度: >98%
溶解度: DMSO: ≥ 100 mg/mL (703.68 mM); Water: 50 mg/mL (351.84 mM)
储存: Store at RT
库存: 现货

Background

Kojic acid is a fungal metabolite that inhibits tyrosinase, an enzyme involved in melanin synthesis, with an IC₅₀ value of 30.6 ?M for mushroom tyrosinase.¹ It decreases growth of Leishmania parasites in vitro and in vivo, and it protects mice from damage induced by gamma irradiation.^2,3 Kojic acid has been used as a food additive to prevent enzymatic browning.⁴ Formulations containing kojic acid are used in the treatment of hyperpigmentation disorders.⁵

1.Lee, Y.S., Park, J.H., Kim, M.H., et al.Synthesis of tyrosinase inhibitory kojic acid derivativeArch. Pharm. (Weinheim)339(3)111-114(2006) 2.Rodrigues, A.P., Farias, L.H., Carvalho, A.S., et al.A novel function for kojic acid, a secondary metabolite from Aspergillus fungi, as antileishmanial agentPLoS One9(3)e91259(2014) 3.Wang, K., Liu, C., Di, C.-J., et al.Kojic acid protects C57BL/6 mice from gamma-irradiation induced damageAsian Pac. J. Cancer Prev.15(1)291-297(2014) 4.Burdock, G.A., Soni, M.G., and Carabin, I.G.Evaluation of health aspects of kojic acid in foodRegul. Toxicol. Pharmacol.33(1)80-101(2001) 5.Kim, Y.M., Yun, J., Lee, C.K., et al.Oxyresveratrol and hydroxystilbene compounds. Inhbitory effect on tyrosinase and mechanism of actionJ. Biol. Chem.277(18)16340-16344(2002)