Iopromide

A contrast reagent

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库存: 现货

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促销价

数量
5mg

￥425.00

340.00

- +
10mg

￥600.00

480.00

- +
25mg

￥1025.00

820.00

- +
50mg

￥1350.00

1080.00

- +
100mg

￥1862.00

1490.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

Iopromide is a non-ionic, water-soluble X-ray contrast agent for intravascular administration.^1,2 Iopromide can cause acute kidney injury and is used in animal models of contrast-induced nephropathy.^3,4

1.Ahn, Y.H., Koh, Y.I., Kim, J.H., et al.The potential utility of iodinated contrast media (ICM) skin testing in patients with ICM hypersensitivityJ. Korean Med. Sci.30(3)245-251(2015) 2.Park, J.Y., Lee, S.K., Kim, J.Y., et al.A new micro-computed tomography-based high-resolution blood-brain barrier imaging technique to study ischemic strokeStroke45(8)2480-2484(2014) 3.Hassan, K., and Fadi, H.Is hypoalbuminemia a prognostic risk factor for contrast-induced nephropathy in peritoneal dialysis patients?Ther. Clin. Risk Manag.10787-795(2014) 4.Wang, N., Wei, R.b., Li, Q.p., et al.Renal Protective Effect of Probucol in Rats with Contrast-Induced Nephropathy and its Underlying MechanismMed. Sci. Monit.212886-2892(2015)

Protocol

Animal experiment:

Mice: Male C57/BL6J mice are randomly divided into 7 groups: control, diabetes mellitus (D), CIN, diabetes mellitus+CIN (DC), diabetes mellitus+Breviscapine (DB), CIN+Breviscapine (CIN+B) and diabetes mellitus+CIN+Breviscapine (DCB). After the model of diabetes mellitus is established, mice are prohibited drinking water for one night, and then mice are injected at a dose of 10 mL/kg iopromide via tail vein administration over the course of 1 minute. Then the mice are treated intragastrically with or without Breviscapine (10 mg/kg/d) for 4 weeks. Other mice groups except for Breviscapine treatment groups (DB, DCB and CIN+B) are administered the same volume of phosphate buffered solution intragastrically for 4 weeks. Then mice are sacrificed by an intraperitoneal injection of chloral hydrate[1].

参考文献:

[1]. Jiang W, et al. Breviscapine attenuatted contrast medium-induced nephropathy via PKC/Akt/MAPK signalling in diabetic mice. Am J Transl Res. 2016 Feb 15;8(2):329-41.
[2]. McCormack PL, et al. Iobitridol: a review of its use as a contrast medium in diagnostic imaging. Clin Drug Investig. 2013 Feb;33(2):155-66.