Utibapril (FPL 63547)

Utibapril (FPL 63547) 是一种具有抗高血压活性的血管紧张素转换酶 (ACE) 抑制剂。

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥6200.00

4960.00

- +
5mg

￥12175.00

9740.00

- +
10mg

￥20762.00

16610.00

- +
20mg

￥36562.00

29250.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

Background

Utibapril is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activities.

Utibapril significantly inhibits plasma, renal, and vascular ACE but not ventricular ACE activity. Utibapril (2 μg/kg/day) significantly inhibits vascular ACE activity, and Utibapril (250 μg/kg/day) results in a significant inhibition of plasma ACE. Furthermore, angiotensin I-induced decreases in coronary flow in the isolated heart are significantly inhibited after treatment with the higher doses of utibapril[1]. FPL 63547 is rapidly and extensively excreted as the diacid in the bile but appeared in the urine in negligible amounts[2].

[1]. Buikema H, et al. Differential inhibition of plasma versus tissue ACE by utibapril: biochemical and functional evidence for inhibition of vascular ACE activity. J Cardiovasc Pharmacol. 1997 May;29(5):684-91. [2]. Carr RD, et al. Preferential biliary elimination of FPL 63547, a novel inhibitor of angiotensin-converting enzyme, in the rat. Br J Pharmacol. 1990 May;100(1):90-4.