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  • CNS-5161 hydrochloride (CNS 5161A)
CNS-5161 hydrochloride (CNS 5161A)的可视化放大

CNS-5161 hydrochloride (CNS 5161A)

CNS-5161 hydrochloride (CNS 5161A) 是一种新型 NMDA 离子通道拮抗剂,可与 NMDA 受体/离子通道位点相互作用,对谷氨酸的作用产生非竞争性阻断。

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CNS-5161 hydrochloride (CNS 5161A)的二维码
  • 库存: 现货
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  • 1mg
    ¥10912.00
    8730.00
    - +
  • 5mg
    ¥21500.00
    17200.00
    - +
  • 10mg
    ¥36562.00
    29250.00
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  • 20mg
    ¥64537.00
    51630.00
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  • 货号: ajce49348
  • CAS: 160756-38-7
  • 别名: CNS 5161A
  • 分子式: C16H19Cl2N3S2
  • 分子量: 388.38
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

CNS-5161 hydrochloride is a novel NMDA ion-channel antagonist that interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.


CNS-5161 (CNS 5161) is a novel and selective noncompetitive antagonist of the NMDA subset of glutamate receptors in the mammalian brain. CNS-5161 has potent inhibitory activity in vitro at the NMDA ion channel and is able to displace [3H] MK-801 binding with a Ki of 1.8 nM in synaptosomal membrane preparations from rat brain[1].


In the neonatal rat NMDA excitotoxicity model in vivo, CNS-5161 (CNS 5161) protects against the necrotic effects of exogenous N-methyl-D-aspartate with an ED80 of 4 mg/kg by the intraperitoneal (i.p.) route. CNS-5161 also shows a 91% inhibition of audiogenic seizures in DBA/2 mice at 4 mg/kg i.p., and has a neuroprotective effect following hypoxix/ischaemic brain injury in neonatal rats[1].


[1]. Walters MR, et al. Early clinical experience with the novel NMDA receptor antagonist CNS 5161. Br J Clin Pharmacol. 2002 Mar;53(3):305-11.

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