SL910102

SL910102是一种非肽类的血管紧张素AT1受体拮抗剂。

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库存: 现货

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数量
1mg

￥15912.00

12730.00

- +
5mg

￥25462.00

20370.00

- +
10mg

￥40762.00

32610.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

SL910102 is a nonpeptide angiotensin AT1 receptor antagonist.

SL910102 (SL 91.0102-90 DL) is a unlabelled nonpeptide AT1-antagonist, which is tested for its ability to compete with [125J](Sar1-Ile8)-angiotensin II for specific AT1-receptor sites in rat lung homogenate[1].

[1]. Soldner A, et al. A radioreceptor assay for the analysis of AT1-receptor antagonists. Correlation with complementary LC data reveals a potential contribution of active metabolites. J Pharm Biomed Anal. 1998 May;17(1):111-24.

Protocol

Kinase experiment:

For saturation as well as displacement studies, rat lung homogenate is incubated in either Hepes-buffer or blank human or rat plasma yielding 50 μg protein per well in a total assay volume of 300 μL. To ensure equilibrium conditions (see binding kinetics), the samples are maintained for 60 min at 25°C under continuous rotation. All experiments are carried out in duplicate, and the results are confirmed with n=3-5 replicates over the following days[1].

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