Guanoxabenz (Hydroxyguanabenz)

Guanabenz (GBZ, GA, Wytensin, Wy-8678,BR-750) is an orally active central alpha 2-adrenoceptor (α2 adrenergic receptor) agonist with antihypertensive action.

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库存: 现货

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1mg

￥2150.00

1720.00

- +
5mg

￥4275.00

3420.00

- +
10mg

￥7262.00

5810.00

- +
20mg

￥12712.00

10170.00

- +

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Background

Guanabenz (GBZ, GA, Wytensin, Wy-8678,BR-750) is an orally active central alpha 2-adrenoceptor (α2 adrenergic receptor) agonist with antihypertensive action.

Interleukin-6 (IL6), colony stimulating factor 2 (Csf2), and cyclooxygenase-2 (Cox2) are downregulated by guanabenz-driven phosphorylation of eukaryotic translation initiation factor 2α (eIF2α). Although expression of IL1β and Tumor Necrosis Factor-α (TNFα) was suppressed by guanabenz, their downregulation was not directly mediated by eIF2α signaling.[2]

[1] B Holmes, et al. Drugs. 1983 Sep;26(3):212-29. [2] Takigawa S, et al. Int J Mol Sci. 2016 May 5;17(5):674.