Desethyl KBT-3022

DesethylKBT-3022是新型抗血小板药物KBT-3022的主要活性代谢物。

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库存: 现货

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1mg

￥7175.00

5740.00

- +
5mg

￥14200.00

11360.00

- +
10mg

￥24787.00

19830.00

- +
20mg

￥43337.00

34670.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

Desethyl KBT-3022 is the main active metabolite of the new antiplatelet agent, KBT-3022.

Pretreatment with desethyl KBT-3022 0.1, 0.3 and 1 mg/kg, i.v. prolongs the time required to achieve thrombotic occlusion in the femoral artery and inhibits collagen-induced platelet aggregation in whole blood ex vivo, each in a dose-dependent manner. Desethyl KBT-3022 inhibits the thrombin-induced aggregation of washed platelets in a concentration-dependent manner 1-40 μM[1].

[1]. Shimazawa M, et al. Antithrombotic effects in a rat model of aspirin-insensitive arterial thrombosis of desethyl KBT-3022, the main active metabolite of a new antiplatelet agent, KBT-3022. Eur J Pharmacol. 1997 Jun 11;328(2-3):183-9.