DM4

A derivative of maytansine

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库存: 现货

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包装

价格

促销价

数量
1mg

￥387.00

310.00

- +
5mg

￥987.00

790.00

- +
10mg

￥1787.00

1430.00

- +
50mg

￥5937.00

4750.00

- +
100mg

￥7500.00

6000.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

DM4 is a thiol-containing derivative of the tubulin polymerization inhibitor maytansine.^1,2 It is cytotoxic to SK-BR-3 cells (IC₅₀ = 3.3 nM).¹ DM4, conjugated to a humanized CD205-targeting monoclonal antibody, is selectively cytotoxic to a variety of CD205-expressing human cancer cells (EC₅₀s = 0.1-1.32 nM) over non-CD205-expressing cells (EC₅₀s = 14.2-22.66 nM) and reduces tumor growth in various mouse xenograft and patient-derived (PDX) cancer models.³

1.Widdison, W.C., Wilhelm, S.D., Cavanagh, E.E., et al.Semisynthetic maytansine analogues for the targeted treatment of cancerJ. Med. Chem.49(14)4392-4408(2006) 2.Remillard, S., Rebhun, L.I., Howie, G.A., et al.Antimitotic activity of the potent tumor inhibitor maytansineScience189(4207)1002-1005(1975) 3.Merlino, G., Fiascarelli, A., Bigioni, M., et al.MEN1309/OBT076, a first-in-class antibody-drug conjugate targeting CD205 in solid tumorsMol. Cancer Ther.18(9)1533-1543(2019)