Fotemustine (S10036)

Fotemustine是一种DNA烷化剂(DNAalkylator)，具有抗肿瘤作用。

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库存: 现货

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数量
5mg

￥637.00

510.00

- +
10mg

￥975.00

780.00

- +
50mg

￥2700.00

2160.00

- +

已选 0 种 0 瓶

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Background

Fotemustine is a DNA-alkylating agent, with antitumor activity.

Fotemustine is a DNA-alkylating agent. Fotemustine (800 μM) decreases GSH and intracellular GSSG levels but increases the extracellular GSSG-levels rapidly in isolated rat hepatocytes[1]. Fotemustine shows inhibitory effect on several tumor cell lines, with IC50s ranging form 0.05 to 0.18 mM[2].

[1]. Brakenhoff JP, et al. Molecular mechanisms of toxic effects of fotemustine in rat hepatocytes and subcellular rat liver fractions. Carcinogenesis. 1996 Apr;17(4):715-24. [2]. Merlin JL, et al. Enhancement of fotemustine (Muphoran) cytotoxicity by amifostine in malignant melanoma cell lines. Anticancer Drugs. 2002 Feb;13(2):141-7.