HaloPROTAC 2

HaloPROTAC 2 (HaloPROTAC 2) 是 E3 和 21 原子长度接头的配体缀合物。接头的接头是卤素基团。 HaloPROTAC 2 包含基于 VH032 的 VHL 配体和 5 单元 PEG 接头。 HaloPROTAC 2 能够在基于细胞的测定中诱导 GFP-HaloTag7 的降解。

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库存: 现货

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5mg

￥4137.00

3310.00

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10mg

￥6900.00

5520.00

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25mg

￥13675.00

10940.00

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货号: ajce49904
CAS: 1799506-06-1
别名: HaloPROTAC 2
分子式: C38H59ClN4O9S
分子量: 783.41
纯度: >98%
溶解度: DMSO : ≥ 50 mg/mL (63.82 mM)
储存: -80°C, protect from light, stored under nitrogen
库存: 现货

Background

HaloPROTAC 2, a chloroalkane-containing PROTAC, induces degradation of HaloTag fusion proteins.

HaloPROTAC 1 and HaloPROTAC2, containing different linker lengths, are synthesized. Their ability to degrade GFP-HaloTag7, (stably expressed in HEK 293 cells) is tested tby flow cytometry, measuring changes in mean fluorescence intensity. While 24 hour treatment with HaloPROTAC 1 leads to less than 20% degradation, the longer HaloPROTAC2 leads to nearly 70% degradation of GFP-Halotag7 at 2.5 μM[1].

[1]. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7.