VBY-825

VBY-825是cathepsin新型可逆抑制剂，对cathepsinB,L,S和V都具有很高的抑制力。

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库存: 现货

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价格

促销价

数量
2mg

￥5637.00

4510.00

- +
5mg

￥10200.00

8160.00

- +
10mg

￥15800.00

12640.00

- +
25mg

￥35925.00

28740.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajce49988
CAS: 1310340-58-9
别名:
分子式: C23H29F4N3O5S
分子量: 535.55
纯度: >98%
溶解度: DMSO : 125 mg/mL (233.40 mM);Water : < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

VBY-825 is a novel, reversible cathepsin inhibitor with high potency against cathepsins B, L, S and V.IC50 value: Target: 130/250/250/330/2.3/4.7 nM(Ki for cathepsin S/L/ZV/Bhumanized-rabbit cathepsin K/cathepsin F) [1]VBY-825 is a potent inhibitor of the assayed cathepsins and its potency against at least one cathepsin, cathepsin S, extends across species relevant for pharmacology studies, specifically mouse. 10 mg/kg/day dose of VBY-825 achieves a trough plasma concentration >200nM, which is well above that required for full inhibition of the intracellular activity of cathepsins B, F, K, L, S and V in both mouse and human cell lines.

[1]. Elie BT, et al. Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model. Biochimie. 2010 Nov;92(11):1618-24.