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  • EMT inhibitor-1
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    EMT inhibitor-1

    EMTinhibitor-1是Hippo,TGF-β和Wnt信号通路的抑制剂,并拥有抗肿瘤活性。

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    EMT inhibitor-1的二维码
    • 库存: 现货
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    • 5mg
      ¥4800.00
      3840.00
      - +
    • 10mg
      ¥7012.00
      5610.00
      - +
    • 25mg
      ¥13887.00
      11110.00
      - +
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    金额: ¥0.00
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    • 货号: ajce50070
    • CAS: 1638526-21-2
    • 别名:
    • 分子式: C12H12Cl2N2O2S
    • 分子量: 319.21
    • 纯度: >98%
    • 溶解度: DMSO : ≥ 5.6 mg/mL (17.54 mM)
    • 储存: Store at -20°C
    • 库存: 现货

    Background

    EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.


    EMT inhibitor-1 (C19) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities, inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro[1].


    EMT inhibitor-1 (C19) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMT inhibitor-1 induces GSK3-β-mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex[1].


    [1]. Basu D, et al. Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-β, and Wnt signaling pathways. Mol Cancer Ther. 2014 Jun;13(6):1457-67.

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