KY1220

KY1220 is a small molecule that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway with IC50 of 2.1 μM in HEK293 reporter cells.

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2mg

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700.00

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5mg

￥1537.00

1230.00

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10mg

￥2500.00

2000.00

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25mg

￥5250.00

4200.00

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50mg

￥9000.00

7200.00

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100mg

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12120.00

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Background

KY1220 is a small molecule that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway with IC50 of 2.1 μM in HEK293 reporter cells.

[1] Pu-Hyeon Cha, et al. Nat Chem Biol. 2016 Aug;12(8):593-600.

Protocol

Cell experiment:

HCT15 or SW480 cells are treated with 25 μM KY1220 or KYA1797K or with control (DMSO) for 72 h. Cell proliferation is measured using the MTT assay. The absorbance of the formazan product is determined at 590 nm every 24 h[1].

参考文献:

[1]. Cha PH, et al. Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation. Nat Chem Biol. 2016 Aug;12(8):593-600.