E3 ligase Ligand-Linker Conjugates 9

E3 ligase Ligand-Linker Conjugates 9 是 E3 和 25 原子长度接头的配体偶联物。接头的接头是卤素基团。 E3 ligase Ligand-Linker Conjugates 9 包含基于 (S,R,S)-AHPC 的 VHL 配体和 6 单元 PEG 接头。 E3 ligase Ligand-Linker Conjugates 9 能够在基于细胞的分析中诱导 GFP-HaloTag7 的降解。

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库存: 现货

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100mg

￥3737.00

2990.00

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500mg

￥14287.00

11430.00

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1g

￥26487.00

21190.00

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2g

￥37075.00

29660.00

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货号: ajce50194
CAS: 1835705-59-3
别名: VH032-PEG6-C4-Cl; VHL Ligand-Linker Conjugates 10; E3 ligase Ligand-Linker Conjugates 9
分子式: C40H63ClN4O10S
分子量: 827.47
纯度: >98%
溶解度: Ethanol: 100 mg/mL (120.85 mM); DMSO: ≥ 100 mg/mL (120.85 mM)
储存: Store at -20°C
库存: 现货

Background

E3 ligase Ligand-Linker Conjugates 9 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.

E3 ligase Ligand-Linker Conjugates 9 uses the VHL ligand[1]. The linker is 6-2-2-2-2-2-2. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. E3 ligase Ligand-Linker Conjugates 9 can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase [2].

[1]. US 20170121321 A1 [2]. Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.