PROTAC BET degrader-2

PROTACBETdegrader-2是一种强效的溴域及末端外(BET)蛋白的降解剂，在RS4;11细胞中测得其对细胞生长的IC50值为9.6nM，并能实现肿瘤消退。

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库存: 现货

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5mg

￥5875.00

4700.00

- +
10mg

￥9087.00

7270.00

- +
25mg

￥19600.00

15680.00

- +

已选 0 种 0 瓶

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货号: ajce50202
CAS: 2093388-33-9
别名:
分子式: C41H42N10O6
分子量: 770.84
纯度: >98%
溶解度: DMSO : 50 mg/mL (64.86 mM);Water : < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression.

PROTAC BET degrader-2 (compound 25) is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression[1].

[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.