SPDB-DM4是ADC的一部分,由maytansinebasedpayload(DM4)和SPDB连接而成,具有高效的抗肿瘤活性。
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SPDB-DM4 is a drug-linker conjugate for ADC by using the maytansinebased payload (DM4) via a SPDB linker, exhibiting potent anti-tumor activity.
[1]. Puja Sapra, et al. Investigational antibody drug conjugates for solid tumors. Journal Expert Opinion on Investigational Drugs Volume 20, 2011-Issue 8.
6-Maleimidohexanoic acid N-hydroxysuccinimide ester (EMCS)
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