KO-947

An ERK inhibitor

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库存: 现货

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促销价

数量
5mg

￥2225.00

1780.00

- +
10mg

￥3087.00

2470.00

- +
25mg

￥6800.00

5440.00

- +
50mg

￥8162.00

6530.00

- +
100mg

￥12625.00

10100.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

KO947 is an ERK inhibitor (IC₅₀ = <50 nM for ERK2).^1,2 It is greater than 50-fold selective for ERK over a panel of 450 kinases.¹ KO947 reduces phosphorylation of the ERK target p90 ribosomal S6 kinase (RSK) in A375 cancer cells containing constitutively active B-RAF^V600E with an IC₅₀ value of less than 250 nM.² It inhibits proliferation of A375 cells, as well as mutant K-Ras-expressing HCT116 and H358 cancer cell lines (IC₅₀s = 50-250 nM for all).

1.Burrows, F., Kessler, L., Chen, J., et al.Abstract 5168: KO-947, a potent ERK inhibitor with robust preclinical single agent activity in MAPK pathway dysregulated tumorsCancer Res.77(13 Suppl.)5168-5168(2017) 2.Li, L., Wu, T., Feng, J., et al.Inhibitors of ERK and methods of use(2015)