(S,R,S)-AHPC-C4-NH2 hydrochloride

(S,R,S)-AHPC-C4-NH2 hydrochloride 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 1 个 linker。用于合成 EED 的靶向PROTAC。

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库存: 现货

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包装

价格

促销价

数量
100mg

￥3775.00

3020.00

- +
500mg

￥14425.00

11540.00

- +
1g

￥26712.00

21370.00

- +
2g

￥37400.00

29920.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajce50474
CAS: 2245697-83-8
别名: VH032-C4-NH2 hydrochloride; VHL Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 28
分子式: C27H40ClN5O4S
分子量: 566.16
纯度: >98%
溶解度: DMSO : ≥ 109.6 mg/mL (193.58 mM)
储存: 4°C, away from moisture
库存: 现货

Background

(S,R,S)-AHPC-C4-NH2 drochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC^[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9.