Niraparib metabolite M1 (Niraparib carboxylic acid metabolite M1)

Niraparib 代谢物 M1 (Niraparib carboxy acid metabolite M1) 是 niraparib 的代谢物，后者作为一种新型聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂。

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货号: ajce51146
CAS: 1476777-06-6
别名: 尼拉帕尼代谢物; Niraparib carboxylic acid metabolite M1; M1 metabolite of niraparib
分子式: C19H19N3O2
分子量: 321.37
纯度: >98%
溶解度: DMSO : ≥ 100 mg/mL (311.17 mM)
储存: Store at -20°C
库存: 现货

Background

Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.

Niraparib metabolite M1 has the validation in plasma and urine for the support of clinical studies such as the mass balance study and the absolute bioavailability study[1].

[1]. van Andel L, et al. Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Nov 19;1040:14-21.