Hydroxycotinine

A metabolite of nicotine

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1mg

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货号: ajce51496
CAS: 34834-67-8
别名: 3'R,5'S)-3'-羟基可替宁
分子式: C10H12N2O2
分子量: 192.21
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
储存: Store at -20°C
库存: 现货

Background

trans-3’-Hydroxycotinine (3HC) is a product of CYP2A6 metabolism of the primary nicotine metabolite, cotinine .^1,2 Cotinine has a longer metabolic half-life compared to 3HC (16 hours vs. 5 hours).¹ The ratio of 3HC to cotinine, termed the nicotine metabolite ratio, correlates with nicotine clearance from the body and is used as a biomarker of CYP2A6 activity.¹ This measure of nicotine metabolism has been used to study tobacco and secondhand smoke exposure as well as to develop pharmacological intervention strategies for smoking cessation.^1,3

1.Zhu, A.Z., Zhou, Q., Cox, L.S., et al.Variation in trans-3'-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intakePLoS One8(8)e70938(2013) 2.von Weymarn, L.B., Retzlaff, C., and Murphy, S.E.CYP2A6- and CYP2A13-catalyzed metabolism of the nicotine Δ5'(1')iminium ionJ. Pharmacol. Exp. Ther.343(2)307-315(2012) 3.Murphy, S.E., Wickham, K.M., Lindgren, B.R., et al.Cotinine and trans 3'-hydroxycotinine in dried blood spots as biomarkers of tobacco exposure and nicotine metabolismJ. Expo. Sci. Environ. Epidermiol.23(5)513-518(2013)