Indolelactic acid

A metabolite of tryptophan

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Background

Indole-3-lactic acid is a metabolite of tryptophan .¹ It is formed from tryptophan by gut microbiota. Indole-3-lactic acid (0.1-10 mM) inhibits LPS-induced production of IL-8 in Caco-2 intestinal epithelial cells. It reduces colon tumor number and size in cancer-prone Apc^+/Min mice when administered at a dose of 20 mg/kg.²

1.Ehrlich, A.M., Pacheco, A.R., Henrick, B.M., et al.Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cellsBMC Microbiol.20(1)357(2020) 2.Sugimura, N., Li, Q., Chu, E.S.H., et al.Lactobacillus gallinarum modulates the gut microbiota and produces anti-cancer metabolites to protect against colorectal tumourigenesisGut71(10)2011-2021(2021)