Pseudouridine

The C-5 glycoside isomer of uridine

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Background

β-Pseudouridine is the C-5 glycoside isomer of the nucleoside uridine .¹ It is formed when uridine in RNA undergoes site-specific isomerization by a pseudouridine synthase enzyme. β-pseudouridine is found in tRNAs from bacteria, archaea, and eukaryotes.² In vitro, it reduces the number of X-ray-induced chromosomal aberrations in human lymphocytes isolated from whole blood in a dose-dependent manner.³

1.Hamma, T., and Ferré-D'Amaré, A.R.Pseudouridine synthasesChem. Biol.13(11)1125-1135(2006) 2.Lorenz, C., Lünse, C.E., and M?rl, M.tRNA modifications: Impact on structure and thermal adaptationBiomolecules7(2)E35(2017) 3.Monobe, M., Arimoto-Kobayashi, S., and Ando, K.β-pseudouridine, a beer component, reduces radiation-induced chromosome aberrations in human lymphocytesMutat. Res.538(1-2)93-99(2003)