N6-Cyclohexyladenosine (CHA)

An A1 adenosine receptor agonist

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
10mg

￥537.00

430.00

- +
50mg

￥1937.00

1550.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

Background

N⁶-Cyclohexyladenosine is an adenosine receptor agonist.¹ It selectively binds to adenosine A₁ receptors in rat cortical membranes (IC₅₀ = 2.3 nM) over A₂ receptors in rat striatal membranes (IC₅₀ = 870 nM). N⁶-Cyclohexyladenosine decreases heart rate and increases coronary flow in a perfused working rat heart model ex vivo (EC₂₅s = 5 and 860 nM, respectively). In vivo, it decreases heart rate and blood pressure in normotensive rats (EC₂₅s = 2.4 and 4.2 μg/kg, respectively).¹ N⁶-Cyclohexyladenosine (100 μM) induces sleep in rats when administered via basal forebrain infusion.² N⁶-Cyclohexyladenosine also decreases locomotor activity in mice (ED₅₀ = 60 μg/kg, i.p.).³

1.Hutchison, A.J., Webb, R.L., Oei, H.H., et al.CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activityJ. Pharmacol. Exp. Ther.251(1)47-55(1989) 2.Blanco-Centurion, C., Xu, M., Murillo-Rodriguez, E., et al.Adenosine and sleep homeostasis in the basal forebrainJ Neurosci.26(31)8092-8100(2006) 3.Nikodijevi?, O., Daly, J.W., and Jacobson, K.A.Characterization of the locomotor depression produced by an A2-selective adenosine agonistFEBS Lett.261(1)67-70(1990)