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Coumetarol (Dicumoxane)

Coumetarol (Dicumoxane) (Dicumoxane) 是一种维生素 K 拮抗剂。

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  • 货号: ajce51804
  • CAS: 4366-18-1
  • 别名: 库美香豆素; Dicumoxane; Ph 137
  • 分子式: C21H16O7
  • 分子量: 380.35
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

Coumetarol (Dicumoxane) is a vitamin K antagonist.


Coumetarol (Dicumoxane), an oral anticoagulant, is active in both models. The vitamin K antagonist Coumetarol is effective in both models after oral treatment but inhibits the thrombus formation more strongly in the arterio-venous shunt model. Treatment with the vitamin K antagonist Coumetarol in a dose of 25 mg/kg p.o. twice daily for 2 days results in a significant reduction in thrombus weight by 50% in the venous stasis model and by 75% in the arterio-venous shunt model. In both experiments the coagulation time as measured by the Thrombotest is prolonged to the same extent[1].


[1]. Vogel GM, et al. Comparison of two experimental thrombosis models in rats effects of four glycosaminoglycans. Thromb Res. 1989 Jun 1;54(5):399-410.

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