25-Hydroxycholesterol

An oxysterol

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库存: 现货

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促销价

数量
5mg

￥425.00

340.00

- +
10mg

￥600.00

480.00

- +
25mg

￥1200.00

960.00

- +
50mg

￥2025.00

1620.00

- +
100mg

￥3137.00

2510.00

- +

已选 0 种 0 瓶

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货号: ajce51962
CAS: 2140-46-7
别名: 25-羟基胆固醇
分子式: C27H46O2
分子量: 402.65
纯度: >98%
溶解度: 20mg/mL in ethanol, 2mg/mL in DMF, 5mg/mL in DMSO (Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

25-hydroxy Cholesterol is an oxysterol.¹ It is formed from cholesterol by cholesterol-25-hydroxylase, and its production can be induced by inflammation or infection.² 25-hydroxy Cholesterol suppresses endogenous cholesterol synthesis by binding to insulin-induced gene (INSIG) proteins and preventing sterol regulatory element binding proteins (SREBPs) from being transported to the Golgi. It inhibits IgA class switching induced by LPS and various cytokines in B cells (IC₅₀ = ~50 nM).³ 25-hydroxy Cholesterol inhibits replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero cells (EC₅₀ = 3.675 ?M) and reduces increases in viral protein production in infected Vero cells when used prior to infection.⁴ It reduces viral RNA loads in the lung and trachea in a mouse model of SARS-CoV-2 infection when administered at a dose of 100 mg/kg per day. Serum levels of 25-hydroxy cholesterol are increased in mice expressing human angiotensin-converting enzyme 2 (hACE2), the functional receptor for SARS-CoV-2, in a model of SARS-CoV-2 infection and in a patient with COVID-19, the primarily respiratory disease caused by SARS-CoV-2.

1.Adams, C.M., Reitz, J., De Brabander, J.K., et al.Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and InsigsJ. Biol. Chem.279(50)52772-52780(2004) 2.Cystger, J.G., Dang, E.V., Reboldi, A., et al.25-Hydroxycholesterols in innate and adaptive immunityNat. Rev. Immunol.14(11)731-743(2014) 3.Bauman, D.R., Bitmansour, A.D., McDonald, J.G., et al.25-Hydroxycholesterol secreted by macrophages in response to toll-like receptor activation suppresses immunoglobulin A productionProc. Natl. Acad. Sci. USA106(39)16764-16769(2009) 4.Zu, S., Deng, Y.-Q., Zhou, C., et al.25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitorCell Res.1-3(2020)