Pipemidic acid

An antibiotic

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100mg

￥537.00

430.00

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Background

Pipemidic acid is an antibiotic and derivative of piromidic acid .¹ It is active against clinical isolates of E. coli, P. mirabilis, P. inconstans, Shigella, Salmonella, Alcaligenes, and V. parahaemolyticus (MICs = 0.78-100 ?g/ml), as well as drug-resistant clinical isolates of E. coli, P. mirabilis, Klebsiella, and Shigella (MICs = 1.56-6.25 ?g/ml). Pipemidic acid is protective against systemic S. aureus, E. coli, K. pneumoniae, and P. aeruginosa infections in mice (ED₅₀s = 237.5, 204.1, 28.6, and 99.5 mg/kg, respectively).² It is also protective against P. aeruginosa-induced pulmonary and dermal infections (ED₅₀s = 81.7 and 173.2 mg/kg, respectively), as well as E. coli, K. pneumoniae, and P. aeruginosa urinary bladder infections (ED₅₀s = 4.8, 11.9, and 30.6 mg/kg, respectively), in mice.

1.Shimizu, Y., Takase, Y., Nakamura, S., et al.Pipemidic acid, a new antibacterial agent active against Pseudomonas aeruginosa: In vitro propertiesAntimicrob. Agents Chemother.8(2)132-138(1975) 2.Shimizu, M., Takdase, Y., Nakamura, S., et al.Pipemidic acid: Its activities against various experimental infectionsAntimicrob. Agents Chemother.9(4)569-574(1976)