Ginkgolic Acid C13:0 (Ginkgolic acid (13:0))

An anacardic acid with diverse biological activities

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库存: 现货

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5mg

￥812.00

650.00

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10mg

￥1350.00

1080.00

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50mg

￥3425.00

2740.00

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货号: ajce52202
CAS: 20261-38-5
别名: 白果新酸,Ginkgolic acid (13
分子式: C20H32O3
分子量: 320.47
纯度: >98%
溶解度: DMF: 30 mg/ml,DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 25 mg/ml,Ethanol: 25 mg/ml
储存: 4°C, protect from light
库存: 现货

Background

Ginkgoneolic acid is an anacardic acid and analog of anacardic acid monoene originally isolated from G. biloba and has diverse biological activities.^1,2,3,4 It inhibits glycerol-3-phosphate dehydrogenase (GPDH; IC₅₀ = 3 μg/ml).¹ Ginkgoneolic acid inhibits PI3Kδ (IC₅₀ = 2.49 μM) and IgE-mediated RBL-2H3 mast cell degranulation in vitro (IC₅₀ = 2.4 μM).² It reduces S. mutans biofilm formation with a 50% biofilm inhibition concentration (MBIC₅₀) value of 4 μg/ml.³ Ginkgoneolic acid is molluscicidal against O. hupensis when used at a concentration of 2 mg/L.⁴

1.Irie, J., Murata, M., and Homma, S.Glycerol-3-phosphate dehydrogenase inhibitors, anacardic acids, from Ginkgo bilobaBiosci. Biotechnol. Biochem.60(2)240-243(1996) 2.Guo, J.-F., Ning, Z.-Q., Wu, X., et al.Discovery of a natural PI3Kδ inhibitor through virtual screening and biological assay studyBiochem. Biophys. Res. Commun.508(3)709-714(2019) 3.He, J., Wang, S., Wu, T., et al.Effects of ginkgoneolic acid on the growth, acidogenicity, adherence, and biofilm of Streptococcus mutans in vitroFolia Microbiol. (Praha)58(2)147-153(2013) 4.Yang, X.-m., Chen, S.-x., Xia, L., et al.Molluscicidal activity against Oncomelania hupensis of Ginkgo bilobaFitoterapia79(4)250-254(2008)