2,2'-Anhydrouridine (2,2'-Cyclouridine)

An inhibitor of uridine phosphorylase

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
100mg

￥537.00

430.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajce52222
CAS: 3736-77-4
别名: 2,2'-脱水尿苷; 2,2'-Cyclouridine; O2,2'-Cyclouridine
分子式: C9H10N2O5
分子量: 226.19
纯度: >98%
溶解度: Soluble in DMSO
储存: Store at -20°C
库存: 现货

Background

Cyclouridine is an inhibitor of uridine phosphorylase (apparent K_i = 2.268 ?M).¹ It is selective for uridine phosphorylase over thymidine phosphorylase at 3.33 mM. Cyclouridine has also been used as a building block in the synthesis of compounds with anticancer or antiviral activities.^2,3

1.Veres, Z., Szabolcs, A., Szinai, I., et al.5-Substituted-2,2'-anhydrouridines, potent inhibitors of uridine phosphorylaseBiochem. Pharmacol.34(10)1737-1740(1985) 2.Ogawa, A., Tanaka, M., Sasaki, T., et al.Nucleosides and nucleotides. 180. Synthesis and antitumor activity of nucleosides that have a hydroxylamino group instead of a hydroxyl group at the 2'- or 3'-position of the sugar moietyJ. Med. Chem.41(25)5094-5107(1998) 3.Sato, Y., Utsumi, K., Maruyama, T., et al.Synthesis and hypnotic and anti-human immunodeficiency virus-1 activities of N3-substituted 2'-deoxy-2'-fluorouridinesChem. Pharm. Bull. (Tokyo)42(3)595-598(1994)