2',3'-Dideoxyadenosine

A prodrug form of ddATP

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10mg

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货号: ajce52230
CAS: 4097-22-7
别名: 2',3'-二脱氧腺苷
分子式: C10H13N5O2
分子量: 235.24
纯度: >98%
溶解度: Water: 100 mg/mL (425.10 mM); DMSO: 100 mg/mL (425.10 mM)
储存: 4°C, protect from light
库存: 现货

Background

2’,3’-Dideoxyadenosine is prodrug form of the nucleoside reverse transcriptase inhibitor (NRTI) 2’,3’-dideoxyadenosine 5’-triphosphate .¹ It inhibits HIV replication in HIV-infected MT-4 cells when used at concentrations of 5 and 125 ?M and protects ATH8 cells against the cytopathic effect of HIV (EC₅₀ = 2.7 ?M).²

1.Schlienger, N., Lefebvre, I., Aubertin, A.-M., et al.Mononucleoside phosphorodithiolates as mononucleotide prodrugsEur. J. Med. Chem.227113914(2022) 2.Herdewijn, P., Blazarini, J., Clercq, E.D., et al.3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agentsJ. Med. Chem.30(8)1270-1278(1987)