Disitertide (P144)

Disitertide (P144) (P144) 是一种肽类转化生长因子-β 1 (TGF-β1) 抑制剂，专门设计用于阻断与其受体的相互作用。 Disitertide (P144) (P144) 也是一种 PI3K 抑制剂和凋亡诱导剂。

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库存: 现货

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1mg

￥950.00

760.00

- +
5mg

￥3775.00

3020.00

- +
10mg

￥6037.00

4830.00

- +
25mg

￥12287.00

9830.00

- +

已选 0 种 0 瓶

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货号: ajce52362
CAS: 272105-42-7
别名: 地司特泰,P144
分子式: C68H109N17O22S2
分子量: 1580.82
纯度: >98%
溶解度: DMSO : ≥ 200 mg/mL (126.52 mM);Water : < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

Disitertide is an inhibitor of TGF-β1.

Disitertide (P144) prevents TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduces binding of TGF-β1 to its receptors. Disitertide blocks TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter[1].

Treatment with Disitertide at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide Disitertide, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4[1].

[1]. Ezquerro IJ et al. A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury. Cytokine. 2003 Apr;22(1-2):12-20.