Hexahydrocurcumin

A natural product and an active metabolite of curcumin

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库存: 现货

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数量
1mg

￥1112.00

890.00

- +
5mg

￥3050.00

2440.00

- +
10mg

￥4862.00

3890.00

- +
25mg

￥9650.00

7720.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

Hexahydrocurcumin is a natural product and an active metabolite of curcumin.¹ It reduces prostaglandin E₂ (PGE₂) production stimulated by phorbol 12-myristate 13-acetate by 37% in human colonic epithelial cells when used at a concentration of 20 ?M. Hexahydrocurcumin (3.125-25 ?M) inhibits overproduction of nitric oxide induced by LPS in RAW 264.7 macrophage cells in a concentration-dependent manner.² It does not affect LPS-induced cytokine release but inhibits LPS-induced iNOS and COX-2 upregulation and NF-κB activation when used at a concentration of 50 ?M. Hexahydrocurcumin prevents the formation of aberrant crypt foci in a dimethylhydrazine rat model of colon cancer and potentiates the effect of 5-fluorouracil .³

1.Ireson, C., Orr, S., Jones, D.J., et al.Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 productionCancer Res.61(3)1058-1064(2001) 2.Zhao, F., Gong, Y., Hu, Y., et al.Curcumin and its major metabolites inhibit the inflammatory response induced by lipopolysaccharide: Translocation of nuclear factor-κB as potential targetMol. Med. Rep.11(4)3087-3093(2015) 3.Srimuangwong, K., Tocharus, C., Tocharus, J., et al.Effects of hexahydrocurcumin in combination with 5-fluorouracil on dimethylhydrazine-induced colon cancer in ratsWorld J. Gastroenterol.18(47)6951-6959(2012)