Herniarin (7-Methoxycoumarin)

A coumarin with diverse biological activities

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100mg

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货号: ajce52538
CAS: 531-59-9
别名: 7-甲氧基香豆素; 7-Methoxycoumarin; Methyl umbelliferyl ether
分子式: C10H8O3
分子量: 176.17
纯度: >98%
溶解度: DMSO : ≥ 125 mg/mL (709.54 mM)
储存: 4°C, protect from light
库存: 现货

Background

7-Methoxycoumarin is a coumarin that has been found in S. oblongifolia and has diverse biological activities.^1,2,3 It reduces the release of prostaglandin E₂ and leukotriene C₄ induced by A23187 in isolated mouse peritoneal macrophages.¹ 7-Methyoxycoumarin is active against S. aureus, S. epidermidis, B. subtilis, S. lutea, and V. cholera (MICs = 0.5, 0.75, 0.75, 0.75, and 0.5 mg/ml, respectively).² In vivo, 7-methoxycoumarin (3.5 and 7 mg/kg) reduces formalin-induced paw licking and biting responses in mice.³

1.Silván, A.M., Abad, M.J., Bermejo, P., et al.Antiinflammatory activity of coumarins from Santolina oblongifoliaJ. Nat. Prod.59(12)1183-1185(1996) 2.Canales-Martínez, M., Hernández-Delgado, T., Flores-Ortiz, C., et al.Antimicrobial activity of Alternanthera caracasanaPharm. Biol.43(4)305-307(2005) 3.Cheriyan, B.V., Sr., Kadhirvelu, P., Sr., Nadipelly, J., Jr., et al.Anti-nociceptive effect of 7-methoxy coumarin from Eupatorium triplinerve vahl (Asteraceae)Pharmacogn. Mag.13(49)81-84(2017)

Protocol

Cell experiment:

Briefly, the cells are seeded (104 cells per well) onto flat-bottomed 96-well culture plates and allowed to grow 72 h after treatment with various concentration of auraptene, Herniarin, umbelliferone, and umbelliprenin. After removing the medium, MTT solution (5 mg/mL in PBS) is added and incubated for 4 h and the resulting formazan is solubilized with DMSO (100 mL). The absorption is measured at 570 nm (620 nm as a reference) in an ELISA reader[1].

参考文献:

[1]. Mousavi SH, et al. Comparative analysis of the cytotoxic effect of 7-prenyloxycoumarin compounds and herniarin on MCF-7 cell line. Avicenna J Phytomed. 2015 Nov-Dec;5(6):520-30.
[2]. Haghighitalab A, et al. Enhancement of cisplatin cytotoxicity in combination with herniarin in vitro. Drug Chem Toxicol. 2014 Apr;37(2):156-62.