Dihydrocoumarin (Hydrocoumarin)

A coumarin with enzyme inhibitory activity

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100mg

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货号: ajce52616
CAS: 119-84-6
别名: 二氢香豆素; Hydrocoumarin; Chroman-2-one
分子式: C9H8O2
分子量: 148.16
纯度: >98%
溶解度: Insoluble in Water; ≥42.2 mg/mL in EtOH; ≥73.6 mg/mL in DMSO
储存: Store at -20°C
库存: 现货

Background

Dihydrocoumarin is a coumarin that has been found in M. officinalis and has enzyme inhibitory activity.^1,2 It inhibits the activities of sirtuin 1 (SIRT1) and SIRT2 (IC₅₀s = 208 and 295 ?M, respectively, for the human enzymes). Unlike coumarin, dietary administration of dihydrocoumarin (0.76%) does not induce hepatocyte vacuolation, bile duct hyperplasia, or cholangiofibrosis.² Formulations containing dihydrocoumarin have been used as flavoring agents.

1.Olaharski, A.J., Rine, J., Marshall, B.L., et al.The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylasesPLoS Genet.1(6)e77(2005) 2.Lake, B.G., Evans, J.G., Lewis, D.F., et al.Comparison of the hepatic effects of coumarin, 3,4-dimethylcoumarin, dihydrocoumarin and 6-methylcoumarin in the ratFood Chem. Toxicol.32(8)743-751(1994)