ASP5878

ASP5878 is a novel FGFR-selective inhibitor with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L for recombinant FGFR1, 2, 3, and 4, respectively.

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库存: 现货

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数量
5mg

￥2537.00

2030.00

- +
10mg

￥4075.00

3260.00

- +
25mg

￥8150.00

6520.00

- +
50mg

￥12912.00

10330.00

- +
100mg

￥18325.00

14660.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajce53194
CAS: 1453208-66-6
别名:
分子式: C18H19F2N5O4
分子量: 407.37
纯度: >98%
溶解度: DMSO : ≥ 250 mg/mL (613.69 mM);Water : < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

ASP5878 is a novel FGFR-selective inhibitor with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L for recombinant FGFR1, 2, 3, and 4, respectively.

ASP5878 inhibits the cell proliferation of HCC cell lines expressing FGF19. ASP5878 inhibits FGFR4 phosphorylation and its treatment results in the suppression of phosphorylation, mobility shift of FRS2, and suppression of ERK phosphorylation in Hep3B2.1-7 cells[1].

Oral administration of ASP5878 at 3 mg/kg induces sustained tumor regression in a subcutaneous xenograft mouse model using Hep3B2.1-7. In HuH-7, an orthotopic xenograft mouse model, ASP5878 induces complete tumor regression and dramatically extended the survival of the mice[1].

[1] Futami T, et al. Mol Cancer Ther. 2017, 16(1):68-75.